Protein Purification
MilliporeSigma™ Calbiochem™ AG 1024
A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity.
MilliporeSigma™ Calbiochem™ Juglone
A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family).
MilliporeSigma™ Calbiochem™ IQ-1
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
MilliporeSigma™ Calbiochem™ Aloisine A
A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects.
MilliporeSigma™ Calbiochem™ BMI-1 Expression Inhibitor, PTC-209
A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
MilliporeSigma™ Calbiochem™ Capsazepine
A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 μM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
MilliporeSigma™ Calbiochem™ Porcn Inhibitor II, C59
A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat
MilliporeSigma™ Calbiochem™ InSolution™ Latrunculin A, Latrunculia magnifica
A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200nM)
MilliporeSigma™ Calbiochem™ Granzyme B Inhibitor I
The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ 2',5'-Dideoxyadenosine
Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 μM), that binds to the adenosine P1 binding site.
MilliporeSigma™ Calbiochem™ Vincristine Sulfate, Apocynaceae sp.
Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.
MilliporeSigma™ Calbiochem™ Caspase-1/4 Inhibitor, VX-765
A cell-permeable prodrug that upon conversion to its active form inhibits caspase-1 and 4 activity (Ki = 800 pM and 600 pM, respectively).
MilliporeSigma™ Calbiochem™ 3-Isobutyl-1-methylxanthine
A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 μM).
MilliporeSigma™ Calbiochem™ G-Protein βγ Binding Peptide, mSIRK
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.
MilliporeSigma™ Calbiochem™ MT1-MMP Inhibitor, NSC405020
The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.